{"id":26,"date":"2022-07-06T12:41:03","date_gmt":"2022-07-06T03:41:03","guid":{"rendered":"https:\/\/tme-tx.com\/jp\/?page_id=26"},"modified":"2025-05-28T11:06:26","modified_gmt":"2025-05-28T02:06:26","slug":"research","status":"publish","type":"page","link":"https:\/\/tme-tx.com\/jp\/research\/","title":{"rendered":"\u7814\u7a76\u958b\u767a"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-1 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p style=\"font-size:20px\"><strong>\u764c\u9593\u8cea\u6291\u5236\u5264\u30fbSTNM01\u306e\u816b\u760d\u5185\u6295\u4e0e\u306e\u610f\u7fa9\uff08MOA\u30e0\u30fc\u30d3\u30fc\uff09<\/strong>\uff1a<\/p>\n\n\n\n<p>\u6975\u3081\u3066\u786c\u304f\u4e4f\u8840\u6027\u3067\u3001\u5168\u8eab\u6295\u4e0e\u85ac\u3092\u52b9\u679c\u7684\u306b\u5230\u9054\u3055\u305b\u308b\u3053\u3068\u304c\u672a\u3060\u96e3\u3057\u3044\u81b5\u764c\u7d44\u7e54\u306b\u5bfe\u3057\u3066\u3001\u8d85\u97f3\u6ce2\u5185\u8996\u93e1\u3067\u76f4\u63a5\u7684\u306b\u6295\u4e0e\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u307e\u305a\u306f\u5f37\u56fa\u306a\u764c\u7d44\u7e54\u69cb\u7bc9\u3092\u307b\u3050\u3059\u4f5c\u7528\u304c\u63aa\u5b9a\u3055\u308c\u307e\u3059\u3002\u307e\u305f\u3001\u5c40\u6240\u6295\u4e0e\u306f\u6240\u5c5e\u30ea\u30f3\u30d1\u7bc0\u306e\u514d\u75ab\u3092\u6d3b\u6027\u5316\u3055\u305b\u308b\u305f\u3081\u306b\u306f\u6709\u52b9\u306a\u6295\u4e0e\u7d4c\u8def\u3067\u3042\u308a\u3001\u6975\u5ea6\u306e\u514d\u75ab\u6291\u5236\u72b6\u614b\u306b\u3042\u308b\u81b5\u764c\u306b\u304a\u3044\u3066\u306f\u3001T\u30ea\u30f3\u30d1\u7403\u306b\u3088\u308b\u6297\u816b\u760d\u514d\u75ab\u306e\u518d\u6d3b\u6027\u5316\u306b\u8ca2\u732e\u3059\u308b\u53ef\u80fd\u6027\u304c\u8003\u3048\u3089\u308c\u307e\u3059\u3002STNM01\u306e\u816b\u760d\u5185\u6295\u4e0e\u306f\u3001\u816b\u760d\u90e8\u306b\u304a\u3044\u3066\u306f\u9593\u8cea\u3092\u307b\u3050\u3059\u3053\u3068\u306b\u3088\u308a\u8840\u4e2d\u306e\u85ac\u5264\u3084\u514d\u75ab\u7d30\u80de\u304c\u5230\u9054\u3057\u3084\u3059\u304f\u306a\u308b\u300c\u5834\u300d\u306b\u5909\u3048\u3001\u307e\u305f\u3001\u30ea\u30e2\u30fc\u30c8\uff08\u30ea\u30f3\u30d1\u7bc0\uff09\u3067T\u30ea\u30f3\u30d1\u7403\u3092\u518d\u6d3b\u6027\u5316\u3055\u305b\u308b\u3068\u3044\u3046\u3001\u816b\u760d\u5c40\u6240-\u30ea\u30f3\u30d1\u7bc0\u306e\u30af\u30ed\u30b9\u30c8\u30fc\u30af\u306b\u3088\u308a\u3001T\u30ea\u30f3\u30d1\u7403\u4f9d\u5b58\u7684\u306a\u6297\u816b\u760d\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u3053\u3068\u304c\u975e\u81e8\u5e8a\u8a66\u9a13\u3067\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div id=\"wpfp_9b0403397fcfb64fa6ecfbef3c340ada\" data-item=\"{&quot;sources&quot;:[{&quot;src&quot;:&quot;https:\\\/\\\/tme-tx.com\\\/jp\\\/wp-content\\\/uploads\\\/sites\\\/3\\\/2025\\\/05\\\/moa_original_1st.mp4&quot;,&quot;type&quot;:&quot;video\\\/mp4&quot;}],&quot;id&quot;:&quot;1&quot;,&quot;splash&quot;:&quot;https:\\\/\\\/tme-tx.com\\\/jp\\\/wp-content\\\/uploads\\\/sites\\\/3\\\/2025\\\/05\\\/moamechanism.jpeg&quot;}\" class=\"flowplayer no-brand is-splash is-paused skin-slim no-svg fp-slim fp-edgy\" style=\"position:relative; max-width: 1024px; max-height: 576px; \" data-ratio=\"0.5625\" data-player-id=\"1\">\n\t<div class=\"fp-ratio\" style=\"padding-top: 56.25%\"><\/div>\n\t<img decoding=\"async\" class=\"fp-splash\" alt=\"video\" src=\"https:\/\/tme-tx.com\/jp\/wp-content\/uploads\/sites\/3\/2025\/05\/moamechanism.jpeg\" style=\"position:absolute;top:0;width:100%\" \/>\n\t<div class=\"fp-ui\"><noscript>Please enable JavaScript<\/noscript><div class=\"fp-play fp-visible\"><svg class=\"fp-play-sharp-fill\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 100 100\"><defs><style>.fp-color-play{opacity:0.65;}.controlbutton{fill:#fff;}<\/style><\/defs><title>play-sharp-fill<\/title><path class=\"fp-color-play\" d=\"M49.9217-.078a50,50,0,1,0,50,50A50.0564,50.0564,0,0,0,49.9217-.078Z\"\/><polygon class=\"controlbutton\" points=\"73.601 50 37.968 70.573 37.968 29.427 73.601 50\" filter=\"url(#f1)\"\/><\/svg><\/div><div class=\"fp-preload\"><b><\/b><b><\/b><b><\/b><b><\/b><\/div><\/div>\n\n<\/div>\n\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:36px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-media-text is-stacked-on-mobile is-vertically-aligned-top\" style=\"grid-template-columns:33% auto\"><figure class=\"wp-block-media-text__media\"><img decoding=\"async\" src=\"https:\/\/tme-tx.com\/wp-content\/uploads\/2025\/04\/tmetx5-1024x656.jpeg\" alt=\"\" class=\"wp-image-524 size-full\"\/><\/figure><div class=\"wp-block-media-text__content\">\n<p>\u81b5\u764c\u306f5\u5e74\u751f\u5b58\u7387\u304c8.5\uff05\u3068\u6975\u3081\u3066\u4e0d\u826f\u306a\u764c\u3067\u3042\u308b\u3002\u5207\u9664\u4e0d\u80fd\u9032\u884c\u81b5\u764c\u306b\u304a\u3044\u3066\u306f\u4e00\u6b21\u5316\u5b66\u7642\u6cd5\uff08\u30d5\u30a1\u30fc\u30b9\u30c8\u30e9\u30a4\u30f3\uff1a1L\u6cbb\u7642\uff09\u3068\u3057\u3066\u30b2\u30e0\u30b7\u30bf\u30d3\u30f3\uff08GEM\uff09\u95a2\u9023\u30ec\u30b8\u30e1\u30f3\u82e5\u3057\u304f\u306f\u30d5\u30eb\u30aa\u30ed\u30a6\u30e9\u30b7\u30eb\u95a2\u9023\u30ec\u30b8\u30e1\u30f3\u306e\u78ba\u7acb\u306b\u3088\u308a\u6cbb\u7642\u6210\u7e3e\u306f\u5411\u4e0a\u3057\u3064\u3064\u3042\u308b\u304c\u3001\u307b\u3068\u3093\u3069\u304c\u4e8c\u6b21\u5316\u5b66\u7642\u6cd5\uff08\u30bb\u30ab\u30f3\u30c9\u30e9\u30a4\u30f3\uff1a2L\u6cbb\u7642\uff09\u3042\u308b\u3044\u306fBSC\uff08\u30d9\u30b9\u30c8\u30fb\u30b5\u30dd\u30fc\u30c6\u30a3\u30d6\u7642\u6cd5\uff09\u3078\u79fb\u884c\u3059\u308b\u30022L\u6cbb\u7642\u306e\u5e73\u5747\u7684\u306a\u5168\u751f\u5b58\u671f\u9593\uff08Overall survival: OS\uff09\u306e\u4e2d\u592e\u5024\u306f4.5\u30f5\u6708\u3001\u30aa\u30cb\u30d0\u30a4\u30c9\u30ec\u30b8\u30e1\u30f3\u30676.1\u30f5\u6708\u3001\u3068\u672a\u3060\u826f\u597d\u3068\u306f\u8a00\u3044\u96e3\u3044\u3002\u6cbb\u7642\u62b5\u6297\u6027\u306e\u539f\u56e0\u3068\u306a\u308b\u75c5\u614b\u3068\u3057\u3066\u300c\u5f37\u56fa\u3067\u8c4a\u5bcc\u306a\u9593\u8cea\u300d\u53ca\u3073\u300c\u6975\u5ea6\u306e\u514d\u75ab\u6291\u5236\u300d\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u3002\u3057\u304b\u3057\u3001\u30ef\u30af\u30c1\u30f3\u3084\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\u306e\u52b9\u679c\u306f\u4ed6\u306e\u764c\u816b\u3068\u6bd4\u8f03\u3057\u3066\u6975\u3081\u3066\u4e4f\u3057\u304f\u3001\u62b5\u6297\u6027\u75c5\u614b\u3092\u6253\u7834\u3059\u308b\u305f\u3081\u3001\u764c\u9593\u8cea\u6291\u5236\u6cbb\u7642\uff08Stromal modifying agents\uff09\u3068\u306e\u30b3\u30f3\u30d3\u30cd\u30fc\u30b7\u30e7\u30f3\u6cbb\u7642\u304c\u671f\u5f85\u3055\u308c\u3066\u304d\u3066\u3044\u308b\u3002<\/p>\n<\/div><\/div>\n\n\n\n<div style=\"height:47px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-media-text is-stacked-on-mobile is-vertically-aligned-top\" style=\"grid-template-columns:33% auto\"><figure class=\"wp-block-media-text__media\"><img decoding=\"async\" src=\"https:\/\/tme-tx.com\/wp-content\/uploads\/2025\/04\/tmetx2-1024x549.jpeg\" alt=\"\" class=\"wp-image-527 size-full\"\/><\/figure><div class=\"wp-block-media-text__content\">\n<p>\u7cd6\u786b\u9178\u8ee2\u79fb\u9175\u7d20CHST15\uff08CHST15\uff09\u306f\u3001\u9ad8\u5ea6\u306b\u786b\u9178\u5316\u3055\u308c\u305f\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u578b\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u3067\u3042\u308b\u30b3\u30f3\u30c9\u30ed\u30a4\u30c1\u30f3\u786b\u9178E\uff08CS-E\uff09\u3092\u5408\u6210\u3059\u308b\u86cb\u767d\u8cea\u3067\u3042\u308b\u3002\u5b9f\u9a13\u7684\u306b\u81b5\u764c\u7531\u6765\u306eCHST15\u3092\u30ea\u30dc\u6838\u9178\uff08RNA\uff09\u5e72\u6e09\uff08RNAi\uff09\u3067\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\uff08KD\uff09\u3059\u308b\u3068\u3001in vitro\u3001in vivo\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u3068\u3082\u306bT\u30ea\u30f3\u30d1\u7403\u4f9d\u5b58\u7684\uff08T cell-dependent anti-tumor effect\uff09\u306a\u816b\u760d\u9664\u53bb\uff08\u6bba\u50b7\uff09\u52b9\u679c\u304c\u8a98\u5c0e\u30fb\u4fc3\u9032\u3055\u308c\u308b\u3002STNM01\u306f\u30d2\u30c8CHST15\uff08hCHST15\uff09\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u6291\u5236\u3059\u308b27mer 2\u672c\u9396RNA\u30aa\u30ea\u30b4\u6838\u9178\u3067\u3042\u308a\u3001RNAi\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3067\u81b5\u764c\u7d30\u80de\u306eCHST15\u30e1\u30c3\u30bb\u30f3\u30b8\u30e3\u30fcRNA\uff08mRNA\uff09\u306b\u7d50\u5408\u3001\u5207\u65ad\u3057\u3001CHST15\u86cb\u767d\u8cea\u306e\u767a\u73fe\u53ca\u3073CS-E\u306e\u751f\u5408\u6210\u3092\u963b\u5bb3\u3059\u308b\u3002<br><br>\u62c5\u764c\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u3092\u7528\u3044\u305fin vivo\u8a66\u9a13\u3067\u306f\u3001\u816b\u760d\u5185\u306b\u8907\u6570\u56de\u6295\u4e0e\u3057\u305fSTNM01\u306f\u3001\u816b\u760d\u5c40\u6240\u306e\u9593\u8cea\u6291\u5236\u52b9\u679c\uff08\u5f37\u56fa\u306a\u7dda\u7dad\u5316\u53ca\u3073\u30cd\u30c8\u30fc\u30b7\u30b9\u3092\u6291\u5236\uff09\u3001\u9aa8\u9ac4\u7531\u6765\u6291\u5236\u7d30\u80de\uff08MDSC\uff09\u6291\u5236\u52b9\u679c\u3068\u540c\u6642\u306bT\u30ea\u30f3\u30d1\u7403\u6d78\u6f64P\u4fc3\u9032\u52b9\u679c\u53ca\u3073T\u30ea\u30f3\u30d1\u7403\u4f9d\u5b58\u7684\u306a\u6297\u816b\u760d\u52b9\u679c\u3092\u793a\u3057\u305f\u3002\u307e\u305f\u30011L GEM + \u30ca\u30d6\u30d1\u30af\u30ea\u30bf\u30ad\u30bb\u30eb\uff08nab-PTX\uff09\u7642\u6cd5\u4e0d\u5fdc\u306e\u5207\u9664\u4e0d\u80fd\u9032\u884c\u81b5\u764c\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7b2c I\/IIa\u76f8\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u30012L\u6cbb\u7642\u3068\u3057\u3066S-1\u7642\u6cd5\u3068\u306e\u4f75\u7528\u3067\u3001\u8d85\u97f3\u6ce2\u5185\u8996\u93e1\u30ac\u30a4\u30c9\u4e0b\u7a7f\u523a\u8853\uff08Endoscopic ultrasound-fine needle injection: EUS-FNI\uff09\u306b\u3088\u308bSTNM01\u306e\u816b\u760d\u5185\u6295\u4e0e\u304c\u5b9f\u65bd\u3055\u308c\u3001\u816b\u760d\u5185T\u30ea\u30f3\u30d1\u7403\u306e\u5897\u52a0\u304c\u8a8d\u3081\u3089\u308c\u305f\u3002\u307e\u305f\u3001\u816b\u760d\u5185T\u30ea\u30f3\u30d1\u7403\u306e\u5897\u52a0\u306e\u7a0b\u5ea6\u3068OS\u3068\u306e\u6b63\u306e\u76f8\u95a2\u304c\u8a8d\u3081\u3089\u308c\u305f\u3002<\/p>\n<\/div><\/div>\n\n\n\n<div style=\"height:47px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-media-text is-stacked-on-mobile is-vertically-aligned-top\" style=\"grid-template-columns:33% auto\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"574\" src=\"https:\/\/tme-tx.com\/jp\/wp-content\/uploads\/sites\/3\/2025\/04\/tmetx7-1024x574.jpeg\" alt=\"\" class=\"wp-image-568 size-full\" srcset=\"https:\/\/tme-tx.com\/jp\/wp-content\/uploads\/sites\/3\/2025\/04\/tmetx7-1024x574.jpeg 1024w, https:\/\/tme-tx.com\/jp\/wp-content\/uploads\/sites\/3\/2025\/04\/tmetx7-300x168.jpeg 300w, https:\/\/tme-tx.com\/jp\/wp-content\/uploads\/sites\/3\/2025\/04\/tmetx7-768x430.jpeg 768w, https:\/\/tme-tx.com\/jp\/wp-content\/uploads\/sites\/3\/2025\/04\/tmetx7-625x350.jpeg 625w, https:\/\/tme-tx.com\/jp\/wp-content\/uploads\/sites\/3\/2025\/04\/tmetx7.jpeg 1280w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<p>\u3053\u308c\u3089\u306e\u6210\u7e3e\u306b\u3088\u308a\u3001STNM01\u306b\u3088\u308aCHST15\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u52b9\u679c\u7684\u306b\u6291\u5236\u3059\u308b\u3068\u3001CHST15\u86cb\u767d\u8cea\u4e26\u3073\u306bCS-E\u306e\u7523\u751f\u4f4e\u4e0b\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u304c\u63a8\u5b9a\u3055\u308c\u3001\u81b5\u764c\u5c40\u6240\u306e\u9593\u8cea\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u75c5\u5de3\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001T\u30ea\u30f3\u30d1\u7403\u4f9d\u5b58\u7684\u306a\u6297\u816b\u760d\u52b9\u679c\u3092\u767a\u63ee\u3057\u5f97\u308b\u3053\u3068\u304b\u3089\u3001\u816b\u760d\u514d\u75ab\u304c\u6291\u5236\u3055\u308c\u3066\u3044\u308b\u5207\u9664\u4e0d\u80fd\u9032\u884c\u81b5\u764c\u306b\u5bfe\u3059\u308b\u65b0\u898f\u533b\u85ac\u54c1\u3068\u3057\u3066\u306e\u6cbb\u7642\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u308b\u3002<\/p>\n<\/div><\/div>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u764c\u9593\u8cea\u6291\u5236\u5264\u30fbSTNM01\u306e\u816b\u760d\u5185\u6295\u4e0e\u306e\u610f\u7fa9\uff08MOA\u30e0\u30fc\u30d3\u30fc\uff09\uff1a \u6975\u3081\u3066\u786c\u304f\u4e4f\u8840\u6027\u3067\u3001\u5168\u8eab\u6295\u4e0e\u85ac\u3092\u52b9 &hellip;<\/p>\n","protected":false},"author":1,"featured_media":696,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-26","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/tme-tx.com\/jp\/wp-json\/wp\/v2\/pages\/26","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/tme-tx.com\/jp\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/tme-tx.com\/jp\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/tme-tx.com\/jp\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/tme-tx.com\/jp\/wp-json\/wp\/v2\/comments?post=26"}],"version-history":[{"count":26,"href":"https:\/\/tme-tx.com\/jp\/wp-json\/wp\/v2\/pages\/26\/revisions"}],"predecessor-version":[{"id":820,"href":"https:\/\/tme-tx.com\/jp\/wp-json\/wp\/v2\/pages\/26\/revisions\/820"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/tme-tx.com\/jp\/wp-json\/wp\/v2\/media\/696"}],"wp:attachment":[{"href":"https:\/\/tme-tx.com\/jp\/wp-json\/wp\/v2\/media?parent=26"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}